Oxygen therapy remains a cornerstone of patient care in various clinical settings. For nurses, mastering oxygen therapy administration is vital to treat hypoxemia, support respiratory function, and improve overall patient outcomes. This guide, updated for 2025, covers the latest evidence-based practices, equipment, safety considerations, and teaching tips to help nurses administer oxygen safely and effectively.
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Introduction to Oxygen Therapy
Oxygen therapy is essential for managing patients with respiratory distress, hypoxemia, or chronic lung diseases. Nurses play a critical role in initiating, monitoring, and adjusting oxygen therapy to ensure patients receive adequate oxygenation without risking complications such as oxygen toxicity or carbon dioxide retention.
- Why It Matters: Adequate oxygen levels are vital for cell function and organ health.
- Role of Nurses: From selecting the appropriate device to educating patients, nurses ensure safe oxygen delivery.


Physiology of Oxygen Therapy
Understanding the basics of oxygen transport and utilization is essential:
Key Concepts
- Oxygen Uptake: Oxygen diffuses across the alveolar-capillary membrane into the bloodstream.
- Oxygen Saturation (SpO2): Measures the percentage of hemoglobin saturated with oxygen; normal levels are 94-98% in healthy adults.
- Hypoxemia: Low blood oxygen levels can lead to organ dysfunction and respiratory distress.
- Hyperoxia Risks: Over-supplementation may lead to oxygen toxicity and pulmonary complications.
Indications and Contraindications
Indications
Oxygen therapy is prescribed for patients experiencing:
- Acute Hypoxemia: Resulting from conditions like pneumonia, ARDS, or cardiac arrest.
- Chronic Respiratory Diseases: Such as COPD and pulmonary fibrosis.
- Post-Operative Recovery: To prevent hypoxia after surgery.
- Trauma: Supporting oxygenation in injured patients.
Contraindications
- Normal Oxygen Levels: Do not administer high oxygen to normoxic patients.
- CO2 Retention: Use caution in patients with COPD prone to hypercapnia.
- Uncontrolled Hyperoxia: Avoid prolonged high oxygen concentrations to prevent toxicity.
Equipment and Oxygen Delivery Devices
Choosing the right device is key to effective oxygen therapy.
Low-Flow Systems
- Nasal Cannula:
- Delivers oxygen at 1-6 L/min.
- Comfortable and allows patients to speak and eat.
- Simple Face Mask:
- Provides moderate oxygen levels.
- May increase dead space if flow is too low.
- Partial/Non-Rebreather Masks:
- Deliver higher oxygen concentrations for critical care.
High-Flow Systems
- Venturi Mask:
- Delivers a precise FiO2 by mixing oxygen with room air.
- High-Flow Nasal Cannula (HFNC):
- Provides warmed, humidified oxygen at up to 60 L/min.
- Mechanical Ventilators:
- Used for patients requiring assisted or controlled ventilation.
Step-by-Step Guide to Oxygen Administration
A systematic approach ensures patient safety and effective therapy.
1. Preparation
- Assess the Patient: Check SpO2, respiratory rate, and signs of distress.
- Review Orders: Verify oxygen flow rate, delivery method, and target saturation.
- Gather Equipment: Include flow meter, tubing, oxygen delivery device, and humidifier (if needed).
2. Administration
- Connect Equipment: Attach the flow meter to the oxygen source, then connect the humidifier and delivery device.
- Adjust Flow Rate: Set according to the prescription.
- Apply the Device:
- Nasal Cannula: Ensure prongs are positioned in the nostrils; secure tubing behind the ears.
- Face Mask: Place over the nose and mouth and secure with straps for a tight seal.
- Verify Function: Check that oxygen is flowing; look for bubbles in the humidifier.
3. Monitoring
- Continuous Assessment: Monitor vital signs, SpO2, and respiratory effort.
- Adjust as Needed: Titrate the flow rate based on patient response.
- Document Findings: Record assessments, flow rate changes, and patient tolerance.
Patient Monitoring and Safety Considerations
Ensuring safety during oxygen therapy is paramount.
Monitoring
- Vital Signs: Monitor heart rate, respiratory rate, and blood pressure.
- Oxygen Saturation: Use a pulse oximeter frequently.
- Patient Comfort: Check for signs of nasal dryness, skin irritation, or respiratory distress.
Safety Precautions
- Fire Hazard: Keep oxygen away from open flames and smoking areas.
- Equipment Checks: Ensure all connections are secure and tubing is free of kinks.
- Patient Education: Instruct patients on device care, cleaning, and emergency procedures.
Nurse Teaching and Patient Education
Effective teaching empowers patients and supports compliance.
Education Strategies
- Explain the Process: Describe why oxygen therapy is needed and how it works.
- Demonstrate Equipment Use: Show how to properly wear and adjust the oxygen delivery device.
- Discuss Safety Measures: Emphasize the importance of keeping oxygen away from heat sources and open flames.
- Provide Written Materials: Offer easy-to-understand handouts or videos for home reference.
- Encourage Questions: Promote an interactive session where patients feel comfortable asking questions.
Frequently Asked Questions
What is the target oxygen saturation for most patients?
For acutely ill patients, the target SpO2 is typically 94-98%. In patients with COPD, it is usually maintained between 88-92%.
What are the common devices used for oxygen delivery?
Common devices include nasal cannulas, simple face masks, non-rebreather masks, Venturi masks, and high-flow nasal cannulas (HFNC).
How should oxygen therapy be monitored?
Nurses should monitor SpO2 using a pulse oximeter, assess vital signs, check for signs of respiratory distress, and document patient responses regularly.
What are the risks of oxygen therapy?
Risks include oxygen toxicity, hypercapnia (especially in COPD patients), nasal or skin irritation, and fire hazards. Careful monitoring and adherence to protocols help minimize these risks.
How can patients be taught to use oxygen safely at home?
Patients should be educated on proper device usage, flow rate settings, routine cleaning and maintenance, and safety precautions, such as keeping oxygen away from heat sources.
Conclusion
Oxygen therapy is a critical intervention in modern healthcare. Nurses must be proficient in assessing patient needs, selecting the appropriate oxygen delivery device, administering oxygen, and monitoring patient response. By following evidence-based guidelines and safety protocols, nurses can provide high-quality, patient-centered care that improves outcomes and enhances patient safety.
Effective nurse teaching on oxygen therapy not only empowers healthcare professionals but also improves patient understanding and adherence to treatment plans. As oxygen therapy evolves, ongoing education and vigilance are key to ensuring safe and effective care in 2025 and beyond.
References and Sources
- National Center for Biotechnology Information (NCBI). (2025). Chapter 11 Oxygen Therapy – Nursing Skills. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK593208/
- Nurseslabs. (2024). Administering Oxygen Therapy. Retrieved from https://nurseslabs.com/administering-oxygen-therapy/
- American Lung Association. (2025). Using Oxygen at Home. Retrieved from https://www.lung.org/lung-health-diseases/lung-procedures-and-tests/oxygen-therapy/using-oxygen-at-home
- World Health Organization (WHO). (2025). Oxygen. Retrieved from https://www.who.int/health-topics/oxygen
- Perry, A. G., Potter, P.A., Ostendorf, W., & Laplante, N. (2021). Applying an Oxygen-Delivery Device. In Clinical Nursing Skills & Techniques (10th ed.). Elsevier.
- Additional relevant guidelines and protocols from AARC and other professional organizations.